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Probing Brain Activity with Micro and Nanoscale Neural Interfaces
Probing Brain Activity with Micro and Nanoscale Neural Interfaces

Date: Monday, February 7, 2011
Time: 4:00 PM
Location: 125 Steele, Caltech
Speaker: Sotiris Masmanidis

Kavli Nanoscience Institute / Microdevices (KNI-MDL) Lab Seminar

In vivo electrophysiology has revealed a wealth of information about the responses of individual neurons to stimuli. Yet studying the brain one cell at a time inherently constrains our ability to understand how the complex interplay of neurons gives rise to behavior. Carrying out large-scale neuronal recordings – simultaneously monitoring the activity of hundreds to thousands of cells across multiple brain areas – will be a transformative advance in systems neuroscience. I will describe the development of implantable microelectrode arrays for massively parallel extracellular readout of brain activity. A new MEMS fabrication and assembly technique has allowed us to increase the spatial density of recording sites via dual-sided and three-dimensional electrode arrays. I will present some applications of such devices in electrophysiological measurements in insects and rodents. In addition, in order to create minimally invasive structures we have utilized nanofabrication techniques to wire up high-density arrays containing a large number of recording sites. I will describe the development 64-channel neural probe with submicron features that is operated by a commercially available application specific integrated circuit.

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