How Do I Rate This?
The blue stars show the average user rating for this item. To add your own rating, move your cursor over the stars to highlight them in gold, and click to show your rating. One star highlighted is the lowest rating, all five is the highest. Once you have rated an item, your rating is added to the average.
Probing Brain Activity with Micro and Nanoscale Neural Interfaces
Kavli Nanoscience Institute / Microdevices (KNI-MDL) Lab Seminar
In vivo electrophysiology has revealed a wealth of information about the responses of individual neurons to stimuli. Yet studying the brain one cell at a time inherently constrains our ability to understand how the complex interplay of neurons gives rise to behavior. Carrying out large-scale neuronal recordings – simultaneously monitoring the activity of hundreds to thousands of cells across multiple brain areas – will be a transformative advance in systems neuroscience. I will describe the development of implantable microelectrode arrays for massively parallel extracellular readout of brain activity. A new MEMS fabrication and assembly technique has allowed us to increase the spatial density of recording sites via dual-sided and three-dimensional electrode arrays. I will present some applications of such devices in electrophysiological measurements in insects and rodents. In addition, in order to create minimally invasive structures we have utilized nanofabrication techniques to wire up high-density arrays containing a large number of recording sites. I will describe the development 64-channel neural probe with submicron features that is operated by a commercially available application specific integrated circuit.