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Single-Cell-Pico-Force-Microscopy: A Novel Tool For High-Resolution Measurements Of Cellular Forces
We have developed a tool we call Single Cell Pico Force Microscopy, capable of measuring cellular forces from individual adherent cells with the high resolution necessary to track macro-molecular force dynamics in living cells. We present our initial results from studies of contracting and relaxing lamellipodia of cells perturbed with Cytochalasin D. We propose a mechanism and quantitative model explaining cellular force disruption by Cytochalasin D. This work illustrates the immense potential of NEMS-based tools for significantly enhanced resolution of cell biology at the single cell level.